Description
DUOTAB TABLETS
Composition:
Each tablet contains Dihydroartemisinin I.P 40mg & Piperaquine Phosphate 320mg as active ingredients.
Description
DUOTAB is a synergistic combination of an artemisinin derivative and a new bisquinoline compound; it is active against the asexual forms of plasmodium, schizonts and gametocytes. Its action on schizonts ensures a rapid decrease of pathogenic parasitaemia which leads to a quick disappearance of clinical signs; its action on gametocytes prevents contamination.
Pharmacokinetics:
The absorption of DUOTAB after oral intake is rapid and complete; it is extensively distributed in all tissues. The half-life of Dihydroartemisinin is very short (around 2 hours) whereas Piperaquine is long (around 9 days).
Indications:
DUOTAB is indicated for the treatment of all kinds of malaria, as long as patients can take oral medications. It is particularly recommended in the case of multi-resistant plasmodium falciparum malaria.
Dosage and Administration:
The patient should follow the doctor’s instructions. The recommended dosage is as follows:
Age Children (2-7yr) Children (8-13yrs) Adults (>14yrs)
Day 1 1 tab 2 tabs 3 tabs
Day 2 1 tab 2 tabs 3 tabs
Day 3 1 tab 2 tabs 3 tabs
Total 3 tabs 6 tbs 9 tabs
Contra-Indications:
DUOTAB is not recommended during the first trimester of pregnancy unless your doctor considers the risk of the disease to be greater.
A new course of Duotab should not be taken within four weeks after the first treatment.
Adverse effects:
Few cases of adverse effects have been reported after the administration of DUOTAB. Most of them are related to Piperaquine affecting the digestive tract (nausea, diarrhoea, loss of appetite, etc.) rare allergic reactions have also been reported (rash, pruritus, etc).
Package:
Blister pack of 3 X 3 tablets per unit box.
Storage:
Do not store above 30°C. Store in a dry place. Protect from direct sunlight.
Preserve in tight and lightproof containers. Keep all medicines out of reach of children
